CFMTI 产品说明书 Chemicals
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产品编号 DC22536
名称 CFMTI

化学性质

CAS 864864-17-5
分子式 C19H16FN5O
分子量 349.3616
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


A potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively; displays >2,000-fold selectivity over mGluR5, and no actvity for other mGluR subtypes; reduces methamphetamine-induced hyperlocomotion and MK-801-induced social withdrawal without any cataleptogenic activities in mice.
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