2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Briciclib inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at nanomolar concentrations (GI50 = 9.8 - 12.2 nM). Cyclin D1 is a protein required for normal progression through the cell cycle and is overexpressed in many tumors. Cyclin D1 expression is regulated through a process termed cap-dependent translation, which requires the function of eukaryotic initiation factor 4E (eIF4E) protein. In vitro evidence indicates that briciclib binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins (c-MYC, VEGF), leading to tumor cell death. Briciclib is potent and shown to be active in nonclinical tumor models when combined with several chemotherapeutics. For the detailed information of Briciclib(ON 013105,ON 014185), the solubility of Briciclib(ON 013105,ON 014185) in water, the solubility of Briciclib(ON 013105,ON 014185) in DMSO, the solubility of Briciclib(ON 013105,ON 014185) in PBS buffer, the animal experiment (test) of Briciclib(ON 013105,ON 014185), the cell expriment (test) of Briciclib(ON 013105,ON 014185), the in vivo, in vitro and clinical trial test of Briciclib(ON 013105,ON 014185), the EC50, IC50,and affinity,of Briciclib(ON 013105,ON 014185), For the detailed information of Briciclib(ON 013105,ON 014185), the solubility of Briciclib(ON 013105,ON 014185) in water, the solubility of Briciclib(ON 013105,ON 014185) in DMSO, the solubility of Briciclib(ON 013105,ON 014185) in PBS buffer, the animal experiment (test) of Briciclib(ON 013105,ON 014185), the cell expriment (test) of Briciclib(ON 013105,ON 014185), the in vivo, in vitro and clinical trial test of Briciclib(ON 013105,ON 014185), the EC50, IC50,and affinity,of Briciclib(ON 013105,ON 014185), Please contact DC Chemicals.
