Briciclib(ON 013105,ON 014185) 产品说明书 Chemicals
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产品编号 DC8179
名称 Briciclib(ON 013105,ON 014185)

化学性质

CAS 865783-99-9
分子式 C19H23O10PS
分子量 474.07
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


Briciclib inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at nanomolar concentrations (GI50 = 9.8 - 12.2 nM). Cyclin D1 is a protein required for normal progression through the cell cycle and is overexpressed in many tumors. Cyclin D1 expression is regulated through a process termed cap-dependent translation, which requires the function of eukaryotic initiation factor 4E (eIF4E) protein. In vitro evidence indicates that briciclib binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins (c-MYC, VEGF), leading to tumor cell death. Briciclib is potent and shown to be active in nonclinical tumor models when combined with several chemotherapeutics. For the detailed information of Briciclib(ON 013105,ON 014185), the solubility of Briciclib(ON 013105,ON 014185) in water, the solubility of Briciclib(ON 013105,ON 014185) in DMSO, the solubility of Briciclib(ON 013105,ON 014185) in PBS buffer, the animal experiment (test) of Briciclib(ON 013105,ON 014185), the cell expriment (test) of Briciclib(ON 013105,ON 014185), the in vivo, in vitro and clinical trial test of Briciclib(ON 013105,ON 014185), the EC50, IC50,and affinity,of Briciclib(ON 013105,ON 014185), For the detailed information of Briciclib(ON 013105,ON 014185), the solubility of Briciclib(ON 013105,ON 014185) in water, the solubility of Briciclib(ON 013105,ON 014185) in DMSO, the solubility of Briciclib(ON 013105,ON 014185) in PBS buffer, the animal experiment (test) of Briciclib(ON 013105,ON 014185), the cell expriment (test) of Briciclib(ON 013105,ON 014185), the in vivo, in vitro and clinical trial test of Briciclib(ON 013105,ON 014185), the EC50, IC50,and affinity,of Briciclib(ON 013105,ON 014185), Please contact DC Chemicals.
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