A-438079 HCl 产品说明书 Chemicals
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产品编号 DC8406
名称 A-438079 HCl

化学性质

CAS 899431-18-6
分子式 C13H10CL3N5
分子量 342.61
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


In 1321N1 cells stably expressing rat P2X7 receptors, A-438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC50 of 321 nM. A-438079 is also selective for the P2X7 receptor, at concentrations up to 100 μM.Intraperitoneal injection of A-438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A-438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg). A-438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A-438079 reduces nociceptive behaviour scores in the HC model. A-438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A-438079 (100 and 300 μmol/kg, i.p.) significantly raises withdrawal thresh-olds in both the SNL and CCI models. For the detailed information of A-438079 HCl, the solubility of A-438079 HCl in water, the solubility of A-438079 HCl in DMSO, the solubility of A-438079 HCl in PBS buffer, the animal experiment (test) of A-438079 HCl, the cell expriment (test) of A-438079 HCl, the in vivo, in vitro and clinical trial test of A-438079 HCl, the EC50, IC50,and affinity,of A-438079 HCl, For the detailed information of A-438079 HCl, the solubility of A-438079 HCl in water, the solubility of A-438079 HCl in DMSO, the solubility of A-438079 HCl in PBS buffer, the animal experiment (test) of A-438079 HCl, the cell expriment (test) of A-438079 HCl, the in vivo, in vitro and clinical trial test of A-438079 HCl, the EC50, IC50,and affinity,of A-438079 HCl, Please contact DC Chemicals.
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