2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.
in vitro: Teneligliptin is a novel chemotype prolylthiazolidine-based DPP-4 inhibitor. The present study aimed to characterize the pharmacological profiles of teneligliptin in vitro and in vivo. Teneligliptin competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC(50) values of approximately 1 nmol/l .
in vivo: Oral administration of teneligliptin in Wistar rats resulted in the inhibition of plasma DPP-4 with an ED(50) of 0.41 mg/kg. Plasma DPP-4 inhibition was sustained even at 24h after administration of teneligliptin. An oral carbohydrate-loading test in Zucker fatty rats showed that teneligliptin at ≥ 0.1mg/kg increased the maximum increase in plasma glucagon-like peptide-1 and insulin levels, and reduced glucose excursions. Six-weeks-old C57BL/6N mice were fed a high-fat diet (60%kcal fat) ad libitum and administered teneligliptin (30 or 60mg/kg) via drinking water for 10 weeks. Mice fed a high-fat diet showed accelerated body weight gain. For the detailed information of Teneligliptin hydrobromide, the solubility of Teneligliptin hydrobromide in water, the solubility of Teneligliptin hydrobromide in DMSO, the solubility of Teneligliptin hydrobromide in PBS buffer, the animal experiment (test) of Teneligliptin hydrobromide, the cell expriment (test) of Teneligliptin hydrobromide, the in vivo, in vitro and clinical trial test of Teneligliptin hydrobromide, the EC50, IC50,and affinity,of Teneligliptin hydrobromide, For the detailed information of Teneligliptin hydrobromide, the solubility of Teneligliptin hydrobromide in water, the solubility of Teneligliptin hydrobromide in DMSO, the solubility of Teneligliptin hydrobromide in PBS buffer, the animal experiment (test) of Teneligliptin hydrobromide, the cell expriment (test) of Teneligliptin hydrobromide, the in vivo, in vitro and clinical trial test of Teneligliptin hydrobromide, the EC50, IC50,and affinity,of Teneligliptin hydrobromide, Please contact DC Chemicals.
