2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Pilaralisib, also known as XL147, is a Class 1 PI3K kinase family inhibitor, and is an orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents including genotoxic agents and receptor tyrosine kinase inhibitors. For the detailed information of Pilaralisib(XL-147; SAR245408), the solubility of Pilaralisib(XL-147; SAR245408) in water, the solubility of Pilaralisib(XL-147; SAR245408) in DMSO, the solubility of Pilaralisib(XL-147; SAR245408) in PBS buffer, the animal experiment (test) of Pilaralisib(XL-147; SAR245408), the cell expriment (test) of Pilaralisib(XL-147; SAR245408), the in vivo, in vitro and clinical trial test of Pilaralisib(XL-147; SAR245408), the EC50, IC50,and affinity,of Pilaralisib(XL-147; SAR245408), For the detailed information of Pilaralisib(XL-147; SAR245408), the solubility of Pilaralisib(XL-147; SAR245408) in water, the solubility of Pilaralisib(XL-147; SAR245408) in DMSO, the solubility of Pilaralisib(XL-147; SAR245408) in PBS buffer, the animal experiment (test) of Pilaralisib(XL-147; SAR245408), the cell expriment (test) of Pilaralisib(XL-147; SAR245408), the in vivo, in vitro and clinical trial test of Pilaralisib(XL-147; SAR245408), the EC50, IC50,and affinity,of Pilaralisib(XL-147; SAR245408), Please contact DC Chemicals.
