GAL-021 is a new intravenous BKCa-channel blocker,well tolerated and stimulates ventilation in healthy volunteers. GAL-021 was safe and generally well tolerated with adverse events comparable with placebo except for an infusion site burning sensation. GAL-021 stimulated ventilation at the highest doses suggesting that greater infusion rates may be required for maximum PD effects. GAL-021 had PK characteristics consistent with an acute care medication.
