| References: |
Tie-2 Inhibitor 7 can permeate the cell (IC50= 1μM) and inhibit endothelial cell tube formation. Research shows that it can block the Tie-2 ligand, Ang-1 (angiopoietin), which induces Tie-2 autophosphorylation and block its downstream signaling with an IC50= 0.3 μM. Vascular leakage, suppression of endothelial apoptosis, and vessel regression are strongly inhibited by Ang-1. The Tie-2 receptor plays a crucial role in the normal and pathologic vascular development of epithelial cells. For the detailed information of Tie-2 inhibitor 7, the solubility of Tie-2 inhibitor 7 in water, the solubility of Tie-2 inhibitor 7 in DMSO, the solubility of Tie-2 inhibitor 7 in PBS buffer, the animal experiment (test) of Tie-2 inhibitor 7, the cell expriment (test) of Tie-2 inhibitor 7, the in vivo, in vitro and clinical trial test of Tie-2 inhibitor 7, the EC50, IC50,and affinity,of Tie-2 inhibitor 7, For the detailed information of Tie-2 inhibitor 7, the solubility of Tie-2 inhibitor 7 in water, the solubility of Tie-2 inhibitor 7 in DMSO, the solubility of Tie-2 inhibitor 7 in PBS buffer, the animal experiment (test) of Tie-2 inhibitor 7, the cell expriment (test) of Tie-2 inhibitor 7, the in vivo, in vitro and clinical trial test of Tie-2 inhibitor 7, the EC50, IC50,and affinity,of Tie-2 inhibitor 7, Please contact DC Chemicals. |
