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产品编号 产品名称 CAS No.
DC21382 EIDD-1931(NHC)

Beta-d-N4-hydroxycytidine 是一种非常有效的抗委内瑞拉马脑炎病毒剂 (anti-VEEV) ,EC50, EC90 和 EC99 分别为 0.426,1.036 和 2.5 μM。

3258-02-4
DC26133 Camostat mesylate

Camostat (FOY305; FOY-S980)甲磺酸盐是胰蛋白酶样蛋白酶抑制剂。

59721-29-8
DC5105 Favipiravir (T-705)

Favipiravir (T-705) 是一种病毒RNA聚合酶 (RNA polymerase) 抑制剂,可转变为其活性形式 Favipiravir-ribofuranosyl-5′-triphosphate (RTP)。Favipiravir-RTP 抑制流感病毒RNA依赖性的RNA聚合酶 (RdRP) 活性,IC50 为 341 nM。

259793-96-9
DC8485 E-64d(Aloxistatin)

Aloxistatin (E64d) 是可渗透细胞,不可逆的广谱半胱氨酸蛋白酶 (cysteine protease) 抑制剂。

88321-09-9
DC22629 GRL-0617

GRL0617 是一种强效、选择性和竞争性的 SARS-CoV PLpro/deubiquitinase 的非共价抑制剂,其 IC50 值为 0.6 μM,Ki 值为 0.49 μM.

1093070-16-6
DC24010 Plpro-IN-6

PLpro inhibitor是PLpro抑制剂,IC50为2.6 uM。

1093070-14-4
DC26230 Furin Inhibitor I

Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LP

150113-99-8
DC26232 DX 600(ACE2 Inhibitor)

DX600 is a potent and selective peptide inhibitor of angiotensin-converting enzyme 2 (ACE2; Kis = 2.8, 200, and 1,200 nM for recombinant, human, and murine ACE2, respectively).

DC26231 Furin Inhibitor II

Hexa-D-arginine (Furin Inhibitor II) 是一种稳定的 furin 抑制剂,对 furin,PACE4 和 PC1 的 Ki 值分别为 106 nM,580 nM 和 13.2 μM。Hexa-D-arginine 在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。

673202-67-0
DC12255 MLN-4760

MLN-4760 是一种有效、选择性的人 ACE2 抑制剂,IC50 值为 0.44 nM,对其选择性是对其他相关蛋白的 5000 多倍,包括人睾丸 ACE (IC50,>100 μM) 和牛 carboxypeptidase A (IC50,27 μM)。

305335-31-3
DCAPI1594 Oseltamivir phosphate

Oseltamivir phosphate (GS 4104) 是一种神经氨酸酶 (neuraminidase) 抑制剂,用于预防和治疗流感 (influenza A 和 B)。

204255-11-8
DC11735 GS-5734(Remdesivir)

Remdesivir (GS-5734) 是一种核苷类似物,具有抗病毒活性,在 HAE 细胞中,对 SARS-CoV 和 MERS-CoV 的 EC50 值为 74 nM,在延迟脑肿瘤细胞中,对鼠肝炎病毒的 EC50 值为 30 nM。Remdesivir 有潜力用于 2019-nCoV (COVID-19) 研究。

1809249-37-3
DC27020 Arbidol analog

A Arbidol analog which showed affinity against both H3 (1150-fold) and H1 (98-fold) hemagglutinin subtypes than Arbidol.

2126032-35-5
DC28041 BIOTIN-PEG4-SBP1(spike-binding peptide 1)

BIOTIN-PEG4-SBP1(spike-binding peptide 1) is a first-in-class peptide binder to the SARS-CoV-2 spike protein.

DC27035 EIDD-2801

EIDD-2801 is an isopropylester prodrug of the ribonucleoside analog N4-hydroxycytidine (NHC, EIDD-1931) that has shown broad anti-influenza virus activity in cultured cells and mice.

2349386-89-4
DC26208 Remdesivir metabolite(GS-441524)

GS-441524 对猫传染性腹膜炎病毒 (FIPV) 有较强的抑制作用,对应的 EC50 值为 0.78 μM。

1191237-69-0
DC28040 SBP1(spike-binding peptide 1)

SBP1(spike-binding peptide 1) is a first-in-class peptide binder to the SARS-CoV-2 spike protein.

DC1008 Telaprevir (VX-950)

Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.

402957-28-2
DC10355 Nelfinavir

Nelfinavir(AG-1341) is a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (Ki=2 nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.

159989-64-7
DC2107 Gemcitabine HCl (Gemzar,LY188011)

Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively,showed potent activity against COVID-19(SARS-COV-2) with EC50 MERS-COV(1.216), SARS-COV(4.957).

122111-03-9
DC21567 Triazavirin

Triazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown efficacy against influenza A and B, including the H5N1 strain. It appears that Triazavirin has shown promise in reducing influenza disease severity and associated complications.5 Given the similarities between SARS-CoV-2 and H5N1, health officials are investigating Triazavirin as an option to combat SARS-CoV-2, the coronavirus responsible for COVID-19.

928659-17-0
DC23149 Oseltamivir acid

Oseltamivir acid (GS 4071, Ro 64-0802, Oseltamivir carboxylate) is a potent inhibitor of influenza neuraminidase (NA) with Ki of <1 nM for both A and B strains,showed potent activity against COVID-19(SARS-COV-2).

187227-45-8
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