GK921

产品编号: DC9855 Featured
GK921
结构式
1025015-40-0
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中国地区超过5000个高品质化合物库存
应用领域
GK921是转谷氨酰胺酶2 (TGase2) 抑制剂,对人类重组TGase2的IC50值为7.71 μM。
Cas No.: 1025015-40-0
名称:
别名: GK-921,GK 921
SMILES: C12=NC=CC=C1N=C(OCCN3CCCC3)C(C#CC4=CC=CC=C4)=N2
分子式: C21H20N4O
分子量: 344.41
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: GK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 uM in cancer cell lines. GK921 inhibited the tgase 2-induced polymerization of I-κBα and p53 in vitro in a dose-dependent manner. Oral administration of GK921 (8 mg/kg) began when tumors reached a volume of 100 mm3 and proceeded for 5 days/week. after 64 days of treatment, tumor volumes were significantly different in GK921-treated mice and vehicle-treated controls.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2856_DC9855_1025015-40-0
COA
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