NVP-BEZ235 Tosylate

产品编号: DC8786 Featured
NVP-BEZ235 Tosylate
结构式
1028385-32-1
此产品仅供科研所需,我们不出售给病人
​我们将匹配市场上最好的价格给您
Email:order@dcbio.cn
免费咨询电话:4008862077
我们的合作伙伴:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
中国地区超过5000个高品质化合物库存
应用领域
Dactolisib Tosylate (BEZ235 Tosylate) 是PI3K和mTOR的双重激酶抑制剂,对PI3Kα, β, γ, δ 的IC50值分别为4, 75, 7, 5 nM。Dactolisib Tosylate (BEZ235 Tosylate) 抑制 mTORC1 和 mTORC2。
Cas No.: 1028385-32-1
名称: 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
别名: BEZ235
SMILES: C(C(C)(C)C#N)1=CC=C(N2C3C4C(N=CC=3N(C)C2=O)=CC=C(C2=CC3C(N=C2)=CC=CC=3)C=4)C=C1.C(S(O)(=O)=O)1=CC=C(C)C=C1
分子式: C37H31N5O4S
分子量: 641.74
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Description of BEZ235: BEZ235 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of NVP-BEZ235 in water, the solubility of NVP-BEZ235 in DMSO, the solubility of NVP-BEZ235 in PBS buffer, the animal experiment(test) of NVP-BEZ235,the in vivo,in vitro and clinical trial test of NVP-BEZ235,the cell experiment(test) of NVP-BEZ235,the IC50, EC50 and Affinity of NVP-BEZ235, please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_2484_DC8786_1028385-32-1
COA
LOT NO. DOWNLOAD
产品编号 产品名称 应用领域
DC12654 PLX8394 PLX8394 是一种有效的,选择性的 BRaf 抑制剂,抑制 BRAFV600E 活性的 IC50 值约为 5 nM。
DC9743 CB1954(Tretazicar) CB1954(Tretazicar) in stock,price: 350 USD/100mg. CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.It can
DC26175 NLX-101(F-15599) NLX-101(F-15599) is a novel compound that activates serotonin 5-HT1A receptors with exceptional selectivity, having over 1000-fold higher affinity for this target over other receptors.
DC26173 YM-53601 YM-53601 is a squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively).
DC26160 Ethosalamide Etosalamide, also known as Ethosalamide, is an antipyretic and analgesics agent.
DC26155 Sulfaphenazole Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Kis = 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).
DC26151 Naloxone (hydrochloride) Naloxone is an opioid inverse agonist drug used to counter the effects of opiate overdose.
DC26139 2-(5-Chloro-1H-indol-2-yl)acetic acid 2-(5-Chloro-1H-indol-2-yl)acetic acid|CAS 720000-48-6
DC12542 GOT1 inhibitor 2c GOT1抑制剂2c是谷氨酸草酰乙酸转氨酶1(GOT1)的一流的非共价抑制剂,IC50为8.2μM。
DC12541 iGOT1-01 iGOT1-01 is a small molecule inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1 (GOT1)) with IC50 of 11.3 uM.