Ceritinib(LDK378)

产品编号: DC5167 Featured
Ceritinib(LDK378)
结构式
1032900-25-6
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中国地区超过5000个高品质化合物库存
应用领域
Ceritinib (LDK378) 是一种选择性,口服可生物利用且具有 ATP 竞争性的 ALK 酪氨酸激酶抑制剂,IC50 为 200 pM。 Ceritinib (LDK378) 还抑制 IGF-1R,InsR 和 STK22D,IC50 值分别为 8、7 和 23 nM。Ceritinib (LDK378) 显示出良好抗肿瘤效力。
Cas No.: 1032900-25-6
名称: 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
别名: LDK-378; LDK378,Ceritinib
SMILES: CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
分子式: C28H36ClN5O3S
分子量: 558.14
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: LDK378 is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell
Kinase Assay:
Cell Assay:
Animal Administration:
References:
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