Nitisinone

产品编号: DC9561 Featured
Nitisinone
结构式
104206-65-7
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中国地区超过5000个高品质化合物库存
应用领域
Nitisinone(SC0735)是4-羟基苯丙酮酸双加氧酶抑制剂。
Cas No.: 104206-65-7
名称:
别名: NTBC;Nitisone;SC0735;Orfadin
SMILES: C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-]
分子式: C14H10F3NO5
分子量: 329.2281
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase. Nitisinone is a drug used to slow the effects of hereditary tyrosinemia type 1. Nitisinone reduced urinary HGA levels from an average of 4.0 +/- 1.8 (SD) g/day to 0.2 +/- 0.2 g/day ( P < .001). Low-dose nitisinone effectively reduced urinary HGA levels in patients with alkaptonuria. Future long-term clinical trials are planned to determine the benefits of nitisinone in preventing joint deterioration and providing pain relief, and its long-term side effects. Nitisinone can prevent the development of liver disease and significantly reduce the risk of developing hepatocellular carcinoma; however, vigorous surveillance for the development of HCC needs to be continued lifelong.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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