AT13148

产品编号: DC7362 Featured
AT13148
结构式
1056901-62-2
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中国地区超过5000个高品质化合物库存
应用领域
AT13148 是一种可口服的,ATP 竞争性的 AGC kinase 的抑制剂,能够抑制 Akt1/Akt2/Akt3,p70S6K,PKA 和 ROCKI/ROCKII 的活性,IC50 值分别为 38 nM/402 nM/50 nM,8 nM,3 nM 和 6 nM/4 nM。
Cas No.: 1056901-62-2
名称: (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol
别名: AT-13148,AT 13148
SMILES: C1=CC(=CC=C1C2=CNN=C2)[C@@](CN)(C3=CC=C(C=C3)Cl)O
分子式: C17H16ClN3O
分子量: 313.78
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was ident
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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