MDK7229(MD2-IN-1)

产品编号: DC24209 Featured
MDK7229(MD2-IN-1)
结构式
111797-22-9
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中国地区超过5000个高品质化合物库存
应用领域
MD2-IN-1 是髓样分化蛋白 2 (MD2) 的抑制剂,对重组人 MD2 (rhMD2) 的 KD 值为 189 μM。
Cas No.: 111797-22-9
名称: (E)-1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
别名: MD2-IN-1; MDK7229; MDK 7229; MDK 7229
SMILES: COC1=C(OC)C(OC)=CC(/C=C/C(C2=CC=C(OC)C(OC)=C2)=O)=C1
分子式: C20H22O6
分子量: 358.141
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: MDK7229, also known as MD2-IN-1 is a MD2 (Myeloid differentiation protein 2) inhibitor. MDK7229 has CAS#111797-22-9. For easy communication, we use its last 4 digit of CAS for name. MDK7229 locked the LPS-induced activation of TLR4/MD2 -downstream pro-inflammatory MAPKs/NF-κB signaling pathways. In a rat model with ALI induced by intracheal LPS instillation, administration MDK7229 exhibited significant protective effect against ALI, accompanied by the inhibition of TLR4/MD2 complex formation in lung tissues.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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