SB290157 trifluoroacetate

产品编号: DC10151 Featured
SB290157 trifluoroacetate
结构式
1140525-25-2
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中国地区超过5000个高品质化合物库存
应用领域
SB290157 trifluoroacetate是有效,选择性的C3a受体的拮抗剂,IC50值为200 nM。
Cas No.: 1140525-25-2
名称:
别名: SB 290157 trifluoroacetate; SB-290157 trifluoroacetate
SMILES: N=C(N)NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O.OC(C(F)(F)F)=O
分子式: C24H29F3N4O6
分子量: 526.51
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: SB 290157, inhibits neutrophil recruitment in a guinea pig LPS-induced airway neutrophilia model and decreases paw edema in a rat adjuvant-induced arthritis model. The antagonist is able to reduce joint swelling only at 3 h, and about 50% inhibition of joint swelling is observed with the concentration of 30 mg/kg. The C3 level is significantly decreased at 3 h compared with naïve mice showing complement consumption. Furthermore, the C3 activation is observed and increased corresponding to the graded concentration of anti-OVA pAb.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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