| References: |
Losartan carboxylic acid is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver.Like the parent compound, losartan carboxylic acid is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation.When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan.8 However, the metabolite has very low oral bioavailability.Losartan, but not its metabolite, inhibits platelet aggregation in vitro. For the detailed information of Losartan Carboxylic Acid, the solubility of Losartan Carboxylic Acid in water, the solubility of Losartan Carboxylic Acid in DMSO, the solubility of Losartan Carboxylic Acid in PBS buffer, the animal experiment (test) of Losartan Carboxylic Acid, the cell expriment (test) of Losartan Carboxylic Acid, the in vivo, in vitro and clinical trial test of Losartan Carboxylic Acid, the EC50, IC50,and affinity,of Losartan Carboxylic Acid, For the detailed information of Losartan Carboxylic Acid, the solubility of Losartan Carboxylic Acid in water, the solubility of Losartan Carboxylic Acid in DMSO, the solubility of Losartan Carboxylic Acid in PBS buffer, the animal experiment (test) of Losartan Carboxylic Acid, the cell expriment (test) of Losartan Carboxylic Acid, the in vivo, in vitro and clinical trial test of Losartan Carboxylic Acid, the EC50, IC50,and affinity,of Losartan Carboxylic Acid, Please contact DC Chemicals. |
