CX-4945 sodium salt(Silmitasertib)

产品编号: DC23942 Featured
CX-4945 sodium salt(Silmitasertib)
结构式
1309357-15-0
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中国地区超过5000个高品质化合物库存
应用领域
Silmitasertib sodium salt 是一种有效、可口服、高度选择性的 CK2 抑制剂,对 CK2α 和 CK2α' 的 IC50值均为 1 nM。
Cas No.: 1309357-15-0
名称: Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[(3-chlorophenyl)amino]-, sodium salt (1:1)
别名: Silmitasertib sodium salt
SMILES: O=C(C1C=CC2C3=CN=CC=C3C(=NC=2C=1)NC1CCCC(Cl)C1)[O-]
分子式: C19H11ClN3NaO2
分子量: 371.7523
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: A potent, selective, orally bioavailable, ATP-competitive inhibitor of protein kinase CK2 with Ki of 0.38 nM, CK2α IC50 of 1 nM; displays good selectivity profile against a panel of 238 kinases; attenuates PI3K/Akt signaling, blocks CK2-dependent HIF-1α transcription, caused cell cycle arrest and selectively induces apoptosis in cancer cells relative to normal cells; exhibits antitumor efficacy in murine xenograft models.Blood CancerPhase 2 Clinical
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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