NVP-CGM097 (CGM-097)

产品编号: DC9769 Featured
NVP-CGM097 (CGM-097)
结构式
1313363-54-0
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中国地区超过5000个高品质化合物库存
应用领域
NVP-CGM097 是一种有效的选择性 MDM2 抑制剂,作用于 hMDM2,IC50 为 1.7±0.1 nM。
Cas No.: 1313363-54-0
名称:
别名: CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097
SMILES: O=C1N(C2=CC=C(N(C)C[C@H]3CC[C@H](N4CC(N(C)CC4)=O)CC3)C=C2)[C@@H](C5=CC=C(Cl)C=C5)C6=C(C=C(OC)C(OC(C)C)=C6)C1
分子式: C38H47ClN4O4
分子量: 659.26
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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