Ys-49

产品编号: DC8094 Featured
Ys-49
结构式
132836-42-1
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中国地区超过5000个高品质化合物库存
应用领域
YS-49 是 PI3K/Akt (RhoA 的下游靶标) 的激活剂,可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。YS-49 能通过诱导血红素加氧酶 (HO-1) 来抑制血管紧张素 II (Ang II) 刺激 VSMC 细胞的增殖。YS-49 是异喹啉化合物生物碱,因能激活心脏 β-adrenoceptors 而具有强烈的正性肌力作用。
Cas No.: 132836-42-1
名称: 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide
别名: YS 49,Ys49
SMILES: C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC=CC4=CC=CC=C43.Br
分子式: C20H20BrNO2
分子量: 386.28
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: YS-49 is a novel positive inotropic isoquinoline compound. YS-49 has potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and atherosclerosis, via the induction of HO-1 gene activity. YS-49 induced HO-1 protein production in a dose-and time-dependent manner in VSMCs. Treatment with YS-49 significantly and dose-dependently inhibited Ang II-induced VSMC proliferation, ROS production, and phosphorylation of JNK, but not P38 MAP kinase or ERK1/2.YS-49(32.8 microM) exhibited much stronger inhibitory effects on TXA(2) formation. The higher inhibitory potencies of YS-49 (IC(50): 3.3microM) than higenamine (IC(50): 140 microM) on AA induced rat platelet aggregation was presumed to be the result of low inhibitory effect of higenamine than YS-49 on TXA(2) production from AA. The oral administration of YS-49 (50 mg/kg) increased the recovery rates from the acute thrombotic challenge in mice and lowered the weight of thrombus formed inside the AV shunt tube in rats. For the detailed information of Ys-49, the solubility of Ys-49 in water, the solubility of Ys-49 in DMSO, the solubility of Ys-49 in PBS buffer, the animal experiment (test) of Ys-49, the cell expriment (test) of Ys-49, the in vivo, in vitro and clinical trial test of Ys-49, the EC50, IC50,and affinity,of Ys-49, For the detailed information of Ys-49, the solubility of Ys-49 in water, the solubility of Ys-49 in DMSO, the solubility of Ys-49 in PBS buffer, the animal experiment (test) of Ys-49, the cell expriment (test) of Ys-49, the in vivo, in vitro and clinical trial test of Ys-49, the EC50, IC50,and affinity,of Ys-49, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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