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BI 882370

产品编号: DC23817 Featured
BI 882370
结构式
1392429-79-6
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中国地区超过5000个高品质化合物库存
应用领域
BI-882370 是一种高效选择性的 RAF 激酶抑制剂，其结合位于 BRAF 激酶的 DFG-out 无活性构象处 (ATP 结合位点)。 BI-882370 抑制 BRAFV600E-mutant, WT BRAF 和 CRAF 激酶的 IC50 值分别为 0.4，0.8 和 0.6 nM。BI-882370 也可以抑制 SRC 家族激酶。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 1392429-79-6
名称: Propane-1-sulfonic acid (3-{5-[(1-ethyl-piperidin-4-yl)-methyl-amino]-3-pyrimidin-5-yl-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluoro-phenyl)-amide
别名: BI882370,BI-882370
SMILES: CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(CC)CC5)C)=CC=C42)=C1F)=O
分子式: C28H33F2N7O2S
分子量: 569.676
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: BI 882370 is a highly potent, selective, orally active RAF inhibitor with IC50 of 0.4, 0.8 and 0.6 nM for BRAF V600E, BRAF WT and CRAF, respectively; demonstrates excellent selectivity (>100-fold) against a panel of 253 kinases (The most sensitive kinase
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_1230_DC23817_1392429-79-6
COA
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