Dihexa (PNB-0408)

产品编号: DC9760 Featured
Dihexa (PNB-0408)
结构式
1401708-83-5
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中国地区超过5000个高品质化合物库存
应用领域
Dihexa,一种寡肽药物,是一种口服活性,血脑屏障可渗透性的血管紧张素 IV 类似物。Dihexa 高亲和力结合肝细胞生长因子 (HGF),Kd 值为 65 pM,并增强了其对受体 c-Met 的活性。Dihexa 在动物模型中显示出优异的抗精神病活性以及改善认知功能。Dihexa 可能有治疗阿尔茨海默症的潜力。
Cas No.: 1401708-83-5
名称:
别名:
SMILES: C1=CC(C[C@@H](NC(=O)CCCCC)C(=O)N[C@H]([C@H](C)CC)C(=O)NCCCCCC(=O)N)=CC=C1O
分子式: C27H44N4O5
分子量: 504.67
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment.[5][6][7][8][9][10] In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2774_DC9760_1401708-83-5
COA
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