Tazemetostat(EPZ-6438)

产品编号: DC7122 Featured
Tazemetostat(EPZ-6438)
结构式
1403254-99-8
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中国地区超过5000个高品质化合物库存
应用领域
Tazemetostat (EPZ-6438) 是一种有效,选择性,口服的 EZH2 抑制剂。Tazemetostat (EPZ-6438) 抑制含有 PRC2 复合体的野生型 EZH2 的活性, Ki 值为 2.5±0.5 nM。Tazemetostat (EPZ-6438) 抑制 EZH2,在肽测定和核小体测定中 IC50 分别为 11 和 16 nM。Tazemetostat (EPZ-6438) 抑制大鼠 EZH2,IC50 为 4 nM。Tazemetostat (EPZ-6438) 还抑制 E
Cas No.: 1403254-99-8
名称: N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
别名: EPZ6438; EPZ 6438; E-7438
SMILES: CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5
分子式: C34H44N4O4
分子量: 572.74
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2enzymatic activity.EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads t
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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