| References: |
AZ5104 is an active circulating metabolite of AZD9291. It shares the similar overall activity profile with AZD9219, but is more potent against mutant EGFR forms, while hitting the wild-type EGFR form at a lower concentration thus demonstrating a smaller selectivity margin compared with the parent. Like AZD9291, AZ5104 displays potent antitumor activities both in vitro and in vivo, and is clinically competent with the parent.AZ5104 is a demethylated metabolite of AZD-9291. AZ-5104 was identified to exhibit 5-fold potency compared to AZD-9291, which is currently in clinical trial. For the detailed information of AZ5104, the solubility of AZ5104 in water, the solubility of AZ5104 in DMSO, the solubility of AZ5104 in PBS buffer, the animal experiment (test) of AZ5104, the cell expriment (test) of AZ5104, the in vivo, in vitro and clinical trial test of AZ5104, the EC50, IC50,and affinity,of AZ5104, For the detailed information of AZ5104, the solubility of AZ5104 in water, the solubility of AZ5104 in DMSO, the solubility of AZ5104 in PBS buffer, the animal experiment (test) of AZ5104, the cell expriment (test) of AZ5104, the in vivo, in vitro and clinical trial test of AZ5104, the EC50, IC50,and affinity,of AZ5104, Please contact DC Chemicals. |
