A 419259 (trihydrochloride)

产品编号: DC9628 Featured
A 419259 (trihydrochloride)
结构式
1435934-25-0
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中国地区超过5000个高品质化合物库存
应用领域
A 419259 trihydrochloride是Src家族激酶抑制剂,对 Src,Lck 和Lyn 的 IC50 分别为9 nM,3 nM,3 nM。
Cas No.: 1435934-25-0
名称:
别名: A419259 trihydrochloride;A-419259 trihydrochloride;RK 20449 trihydrochloride;RK20449 trihydrochloride;RK-20449 trihydrochloride
SMILES: CN1CCN(CC1)C2CCC(CC2)N3C=C(C4=C3N=CN=C4N)C5=CC=C(C=C5)OC6=CC=CC=C6.Cl.Cl.Cl
分子式: C29H37Cl3N6O
分子量: 592.0027
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: A 419259 3Hcl is an apoptosis inducing agent that inhibits Src family kinases (c-Src). A 419259 also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation. in vitro: Treatment of the Ph+ CML cell lines K-562 and Meg-01 with A-419259 resulted in growth arrest and induction of apoptosis, while the Ph- leukemia cell lines TF-1 and HEL were unaffected over the same concentration ranges. Suppression of Ph+ cell growth by A-419259 correlated with a decrease in Src kinase autophosphorylation. A-419259 blocked Stat5 and Erk activation, consistent with the suppressive effects of the compounds on survival and proliferation. A-419259 treatment blocks all Src-family kinase activity in ES cells, preventing differentiation while maintaining pluripotency. Expression of inhibitor-resistant c-Src but not c-Yes rescued the A-419259 differentiation block, resulting in a cell population with properties of both primitive ectoderm and endoderm. Blockade of Src family kinases using an Src-specific tyrosine kinase inhibitor A-419259 decreased GRP-induced EGFR phosphorylation and MAPK activation in HNSCC.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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