| References: |
UM729 has been found to be a new pyrimidoindole and have an additive efficacy with AhR antagonists in preventing differentiation in most AML specimen. In addition, UM729 has been reported to expand mormal HSPCs in a AhR-independent fashion. Moreover, UM729 has shown an additive effect with AhR inhibitors(SR1) on the ex vivo culture of primary human AML cells（05H163 cells） and progenitor cells . Besides, UM729 has been revealed to expand HSCs and synergize with SR1 to enhance human HSC expansion, result in successful long-term engraftment of SCID repopulating cells (SRCs) in immunodeficient mice. For the detailed information of UM729, the solubility of UM729 in water, the solubility of UM729 in DMSO, the solubility of UM729 in PBS buffer, the animal experiment (test) of UM729, the cell expriment (test) of UM729, the in vivo, in vitro and clinical trial test of UM729, the EC50, IC50,and affinity,of UM729, For the detailed information of UM729, the solubility of UM729 in water, the solubility of UM729 in DMSO, the solubility of UM729 in PBS buffer, the animal experiment (test) of UM729, the cell expriment (test) of UM729, the in vivo, in vitro and clinical trial test of UM729, the EC50, IC50,and affinity,of UM729, Please contact DC Chemicals. |
