HTHQ

产品编号: DC9960 Featured
HTHQ
结构式
148081-72-5
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中国地区超过5000个高品质化合物库存
应用领域
HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) 是一种强力的亲脂性酚类抗氧化剂。HTHQ 通过与活性氧 (ROS) 直接反应并清除 ROS 以形成更稳定的自由基而具有很强的抗氧化活性。
Cas No.: 148081-72-5
名称:
别名:
SMILES: OC1=C(C)C=C(OCCCCCC)C(C)=C1C
分子式: C15H24O2
分子量: 236.35
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: HTHQ, which is a hydroquinone monoalkyl ether, is a potent anti-oxidative agent, even at low dose levels. HTHQ is found to be a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals.In vitro: HTHQ exhibits a similar anti-oxidative activity to that of D,L-alpha-tocopherol against lipid peroxidation in linolate micelles initiated by addition of Fe2+. HTHQ exhibits approximately 4.8-fold higher anti-lipid-peroxidation activity than that of D,L-alpha-tocopherol against the peroxidation in phosphatidylcholine liposomes initiated by addition of Fe2+.up to 0.125% HTHQ significantly reduced the effects of 0.02% Glu-P-1 or 0.03% MeIQx on the number and area of foci. In vivo: Treatment with HTHQ potently inhibits PhIP-induced mammary carcinogenesis in female rats without prior initiation treatment. . HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue. In this study, we showed that HTHQ improves against DMN-induced liver fibrosis in male SD rats.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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