| References: |
Dp44mT shows pronounced antiproliferative effects in SK-N-MC, SK-Mel-28, and MCF-7 cells with IC50 of 30 nM, 60 nM, and 60 nM, respectively, while no effects on normal MRC-5 fibroblasts. Dp44mT inhibits cellular Fe uptake from Fe-Tf in SK-N-MC neuroepithelioma and M109 cells, and induces cell apoptosis. In MDA-MB-231 cells, Dp44mT specifically targets topoisomerase topo2α, and thus causes DNA damage. Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp). In CD2F1 mice bearing M109 tumors, Dp44mT (0.4 mg/kg, i.v.) inhibits tumor growth in a dose-dependent manner. For the detailed information of Dp44mT, the solubility of Dp44mT in water, the solubility of Dp44mT in DMSO, the solubility of Dp44mT in PBS buffer, the animal experiment (test) of Dp44mT, the cell expriment (test) of Dp44mT, the in vivo, in vitro and clinical trial test of Dp44mT, the EC50, IC50,and affinity,of Dp44mT, For the detailed information of Dp44mT, the solubility of Dp44mT in water, the solubility of Dp44mT in DMSO, the solubility of Dp44mT in PBS buffer, the animal experiment (test) of Dp44mT, the cell expriment (test) of Dp44mT, the in vivo, in vitro and clinical trial test of Dp44mT, the EC50, IC50,and affinity,of Dp44mT, Please contact DC Chemicals. |
