Abiraterone (D4A)

产品编号: DC24211 Featured
Abiraterone (D4A)
结构式
154229-21-7
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中国地区超过5000个高品质化合物库存
应用领域
D4-abiraterone 是阿比特龙的主要代谢产物。D4-abiraterone 是 CYP17A1, 3β-羟基类固醇脱氢酶 (3 βHSD) 和类固醇-5α-还原酶 ( SRD5A ) 的抑制剂,也是雄激素受体的拮抗剂。
Cas No.: 154229-21-7
名称: 17-(3-pyridinyl)-androsta-4,16-dien-3-one
别名:
SMILES: O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CN=CC=C5)=C1
分子式: C24H29NO
分子量: 347.5
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Abiraterone (D4A) is an androgen receptor antagonist (IC50 = 5.3 nM) that reduces expression of the androgen receptor target genes PSA, TMPRSS2, and FKBP5 in LNCaP, LAPC4, and C4-2 cell lines. It inhibits the cytochrome P450 (CYP) isoform CYP17A1 by 66.5% when used at a concentration of 1 nM. D4A (10 μM) also blocks SRD5A conversion of Δ4-androstenedione to 5α-androstanedione in LAPC4 cells. In vivo, D4A delays tumor progression in a VCaP mouse xenograft model and increases progression-free survival in a C4-2 mouse xenograft model.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_1255_DC24211_154229-21-7
COA
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