L-755,507

产品编号: DC8092 Featured
L-755,507
结构式
159182-43-1
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中国地区超过5000个高品质化合物库存
应用领域
L755507 是一个有效的, 选择性强的 β3-AR 激动剂, 其 IC50 值为 35 nM。
Cas No.: 159182-43-1
名称: 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
别名: L755,507,L-755507,L 755,507
SMILES: CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNC[C@@H](COC3=CC=C(C=C3)O)O
分子式: C30H40N4O6S
分子量: 584.73
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: L-755,507 enhance CRISPR-mediated HDR efficiency, 3-fold for large fragment insertions and 9-fold for point mutations. L-755,507 was previously characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 ~0.43 nM. It has > 1000 fold selectivity overβ1- and β2-adrenoceptors (EC50 ~ 580 nM and >10000 nM for β1- and β2-adrenoceptors respectively). It stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM).In vitro: L-755,507 was used at 1-5 µM final concentration in various in vitro assays.In vivo: L-755,507 stimulates metabolic rate by 30% after acute bolus intravenous administration of 0.1 mg/kg to rhesus monkeys. For the detailed information of L-755,507, the solubility of L-755,507 in water, the solubility of L-755,507 in DMSO, the solubility of L-755,507 in PBS buffer, the animal experiment (test) of L-755,507, the cell expriment (test) of L-755,507, the in vivo, in vitro and clinical trial test of L-755,507, the EC50, IC50,and affinity,of L-755,507, For the detailed information of L-755,507, the solubility of L-755,507 in water, the solubility of L-755,507 in DMSO, the solubility of L-755,507 in PBS buffer, the animal experiment (test) of L-755,507, the cell expriment (test) of L-755,507, the in vivo, in vitro and clinical trial test of L-755,507, the EC50, IC50,and affinity,of L-755,507, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2133_DC8092_159182-43-1
COA
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