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ML RR-S2 CDA ammonium salt

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ML RR-S2 CDA ammonium salt
结构式
1638750-96-5
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中国地区超过5000个高品质化合物库存
应用领域
ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt; MIW815 ammonium salt) 是干扰素基因刺激物的激活剂 (STING)，具有有效的抗肿瘤和免疫活性。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 1638750-96-5
名称: Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2)
别名: STING-Inducer-1 ammonium salt
SMILES: OC1([H])[C@](O[P@]([S-])(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C7=NC=NC(N)=C7N=C6)O[C@]1([H])CO[P@]5([S-])=O.[NH4+].[NH4+]
分子式: C20H30N12O10P2S2
分子量: 724.604124
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: ML RR-S2 CDA ammonium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles; shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C; also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP; demonstrates profound anti-tumor efficacy in established B16 melanoma.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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