Dutasteride

产品编号: DC8825 Featured
Dutasteride
结构式
164656-23-9
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中国地区超过5000个高品质化合物库存
应用领域
Dutasteride (GG745)是5α 还原酶同工酶 (5α-reductase isozymes) 抑制剂,还可能因其结构域DHT相似对雄激素受体 (AR) 产生脱靶效应。
Cas No.: 164656-23-9
名称: 1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol
别名: GI 198745
SMILES: O=C1N[C@]([H])2CC[C@@]3([C@]4(CC[C@@H](C(=O)NC5C(C(F)(F)F)=CC=C(C(F)(F)F)C=5)[C@]4(C)CC[C@@]3([H])[C@]2(C)C=C1)[H])[H]
分子式: C27H30F6N2O2
分子量: 528.53
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Dutasteride is a 5-α-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). Dutasteride inhibits both isoforms of 5-α reductase (5 α-Reductase 1/5aR1 and 5 α-Reductase 2/5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competed for binding the LNCaP cell AR with an IC50 approximately 1.5 μM.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2518_DC8825_164656-23-9
COA
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