TBB

产品编号: DC9400 Featured
TBB
结构式
17374-26-4
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中国地区超过5000个高品质化合物库存
应用领域
TBB是可渗透细胞,ATP竞争型的 CK2 抑制剂,抑制大鼠肝脏CK2的 IC50 值为0.15 μM。
Cas No.: 17374-26-4
名称:
别名: NSC 231634; TBB (enzyme inhibitor);1H-Benzotriazole, 4,5,6,7-tetrabromo-
SMILES: C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br
分子式: C6HBr4N3
分子量: 434.7083
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). TBB exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. TBB acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. The effect of TBB on PC-3 human prostate cancer cell viability depends on the time schedule of administration.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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