EN6

产品编号: DC24204 Featured
EN6
结构式
1808714-73-9
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中国地区超过5000个高品质化合物库存
应用领域
EN6 是一种小分子体内自噬 (autophagy) 激活剂,其共价靶向溶酶体v-ATP 酶的 ATP6V1A 亚基中的半胱氨酸 277。EN6 介导的 ATP6V1A 修饰使 v-ATP 酶与 Rag 解偶联,导致 mTORC1 信号传导的抑制,溶酶体酸化增加和自噬激活。EN6 以溶酶体依赖性方式清除 TDP-43 聚集物,这是额颞叶痴呆的致病因子。
Cas No.: 1808714-73-9
名称: 1H-Pyrazole-4-carboxamide, N-[4-fluoro-3-[(1-oxo-2-propen-1-yl)amino]phenyl]-1-(2-fluorophenyl)-
别名: EN-6,EN 6
SMILES: FC1C=CC(NC(C2C=NN(C3C=CC=CC=3F)C=2)=O)=CC=1NC(=O)C=C
分子式: C19H14F2N4O2
分子量: 368.34
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: EN6 is a covalent ligand that uniquely targets a novel ligandable cysteine within the ATP6V1A component of the v-ATPase complex to inhibit mTORC1 signaling and activate autophagy to improve cellular clearance.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_1249_DC24204_1808714-73-9
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