LXS-196

产品编号: DC26012 Featured
LXS-196
结构式
1874276-76-2
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中国地区超过5000个高品质化合物库存
应用领域
LXS196 是有效的、选择性的和具有口服活性的蛋白激酶C (PKC) 抑制剂,对PKCα、PKCθ 和 GSK3β 的 IC50 值分别为 1.9 nM、0.4 nM 和 3.1 μM。有潜力用于葡萄膜黑素瘤的研究。
Cas No.: 1874276-76-2
名称:
别名: NVP-LXS196; NVPLXS196; NVP LXS196; LXS-196; LXS 196; LXS196; LXS-196
SMILES: NC1=C(C(NC2=C(N3CCC(C)(N)CC3)C=CC=N2)=O)N=C(C4=NC=CC=C4C(F)(F)F)C=N1
分子式: C22H23F3N8O
分子量: 472.19
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: LXS-196 is a potent and orally active protein kinase C inhibitor for the treatment of uveal melanoma. Upon oral administration, protein kinase C inhibitor LXS196 binds to and inhibits PKC, which prevents the activation of PKC-mediated signaling pathways. This may lead to the induction of cell cycle arrest and apoptosis in susceptible tumor cells. PKC, a serine/threonine protein kinase overexpressed in certain types of cancer cells, is involved in tumor cell differentiation, proliferation, invasion and survival.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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