dBET57

产品编号: DC21893 Featured
dBET57
结构式
1883863-52-2
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中国地区超过5000个高品质化合物库存
应用领域
dBET57 是一种有效选择性的 BRD4BD1 降解剂,基于 PROTAC 技术。dBET57 介导了 E3 泛素连接酶 CRL4CRBN 的招募,对 BRD4BD1 作用的 DC50/5h 值为 500 nM,对 BRD4BD2 不起作用。
Cas No.: 1883863-52-2
名称: 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide
别名: dBET57,dBET 57,dBET-57
SMILES:
分子式: C34H31ClN8O5S
分子量: 699.183
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_1098_DC21893_1883863-52-2
COA
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