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Dioscin

产品编号: DC9834 Featured
Dioscin
结构式
19057-60-4
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中国地区超过5000个高品质化合物库存
应用领域
Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷，针对多种癌细胞有较好的抗癌活性。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 19057-60-4
名称:
别名: Collettiside III; CCRIS 4123
SMILES: C[C@]1([C@](C2)([H])[C@@](CC=C3[C@]4(C)CC[C@H](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]7[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7)[C@@H](CO)O5)C3)([H])[C@]4([H])CC1)[C@]8([H])[C@@]2([H])O[C@]9(CC[C@@H](C)CO9)[C@H]8C
分子式: C45H72O16
分子量: 869.04
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines in vitro: dioscin (1, 2 and 4 μmol/L) could significantly inhibit the viability of LNCaP cells in a time- and concentration-dependent manner. Flow cytometry revealed that the apoptosis rate was increased after treatment of LNCaP cells with dioscin for 24 h, indicating that apoptosis was an important mechanism by which dioscin inhibited cancer. dioscin abrogated AKT phosphorylation, which subsequently impaired RANKL-induced nuclear factor-kappaB (NF-κB) signaling pathway and inhibited NFATc1 transcriptional activity. Moreover, in vivo studies further verified the bone protection activity of dioscin in osteolytic animal model. Dioscin reduced cell death and lactate dehydrogenase (LDH) release in cells subjected to I/R. I/R induced apoptosis and cytochrome c release from mitochondria to the cytosol and this was prevented by dioscin. In support, dioscin decreased Bax but increased Bcl-2 mRNA expression. Dioscin prevented I/R induced dissipation of ΔΨm.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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