RET-IN-1

产品编号: DC24201 Featured
RET-IN-1
结构式
2222755-14-6
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中国地区超过5000个高品质化合物库存
应用领域
RET-IN-1是一种有效的 RET 激酶抑制剂,抑制 RET (WT),RET (V804M) 和 RET (G810R),IC50 分别为 1 nM,7 nM 和 101 nM,详细信息请参考专利文献 WO2018071447A1 中的化合物 Example 552。
Cas No.: 2222755-14-6
名称:
别名: LOXO-292; LOXO292; LOXO 292; ARRY-192; ARRY192; ARRY 192
SMILES: N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[C@H]7CNCCO7)=CN2N=C1
分子式: C29H31N9O3
分子量: 553.255
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: LOXO-292 is an investigational, novel, potent, orally active and selective drug candidate that is in clinical development for the treatment of patients with cancers that harbor abnormalities in the rearranged during transfection (RET) kinase. Genomic alt
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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