BAY-293

产品编号: DC23825 Featured
BAY-293
结构式
2244904-70-7
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中国地区超过5000个高品质化合物库存
应用领域
BAY-293 是一种有价值的化学探针,通过破坏 KRAS-SOS1 相互作用从而阻断 RAS 活化,IC50 为 21 nM。BAY-293 是一种有效的 SOS1 抑制剂。SOS1 是一种鸟苷酸交换因子 (GEF),也是 RAS 的激活剂。
Cas No.: 2244904-70-7
名称: (R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine
别名: BAY-293,BAY 293,BAY293
SMILES:
分子式: C25H28N4O2S
分子量: 448.585
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: BAY-293 (BAY293, BAY 293) is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM; displays no significant activity against KRAS WT-CRAF RBD, CDC42 and EGFR (>20 uM); blocks reloading of KRAS with GTP, does not s
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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