RU-521

产品编号: DC22305 Featured
RU-521
结构式
2262452-06-0
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中国地区超过5000个高品质化合物库存
应用领域
RU.521 (RU320521) 是一种有效的,选择性的环状 GMP-AMP 合成酶 (cGAS) 抑制剂,抑制 cGAS 介导的干扰素上调。RU.521 也抑制 dsDNA 激活受体的活性,IC50 为 700 nM。RU.521 可以降低来自 Aicardi-Goutières 综合征小鼠模型的巨噬细胞中干扰素的组成型表达。
Cas No.: 2262452-06-0
名称: 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one
别名: RU.521;RU521;RU-320521
SMILES:
分子式: C19H12Cl2N4O3
分子量: 415.23
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: RU-521 (RU.521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM; inhibits cGAS-mediated interferon upregulation in cellular assays, with no effect on inflammatory pathways independent of cGAS; suppresses the chronically elevated levels of type I interferon in primary macrophages from mice model of AGS (Aicardi-Goutières syndrome).
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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