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Golotimod (SCV-07)

产品编号: DC26017 Featured
Golotimod (SCV-07)
结构式
229305-39-9
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中国地区超过5000个高品质化合物库存
应用领域
Golotimod (SCV-07)，一种具有抗菌活性的免疫调节肽，可显着提高抗结核治疗的功效，刺激胸腺和脾细胞增殖，并改善巨噬细胞功能。Golotimod (SCV-07) 抑制 STAT3 信号传导并调节接受放疗或放疗与顺铂联合用药的动物模型中口腔粘膜炎的持续时间和严重程度。Golotimod (SCV-07) 是复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 的潜在治疗药物。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 229305-39-9
名称: (R)-2-amino-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid
别名: SCV 07; SCV-07; SCV07; gammaDglutamylLtryptophan
SMILES: O=C(O)[C@H](N)CCC(N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2)=O
分子式: C16H19N3O5
分子量: 333.34
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Golotimod, also known as Orilotimod, SCV-07, is an orally bioavailable synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities. Although the exact mechanism of action is unknown, golotimod appears to inhibit the expression of STAT-3, reversing immunosuppression and stimulating an anti-tumor immune response. This agent may stimulate the production of T-lymphocytes (in particular the helper T [Th1] cells), activate macrophages, and increase levels of interleukin 2 and interferon gamma. STAT-3, a transcription factor upregulated in many cancer cell types, is involved in tumor cell growth and survival and immunosuppression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Kinase Assay:
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Animal Administration:
References:
MSDS
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MSDS_1276_DC26017_229305-39-9
COA
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