TRi-1(TXNRD1 inhibitor 1)

产品编号: DC22309 Featured
TRi-1(TXNRD1 inhibitor 1)
结构式
246020-68-8
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中国地区超过5000个高品质化合物库存
应用领域
TRi-1 是有效的、特异性的、不可逆的胞质硫氧还蛋白还原酶1 (TXNRD1) 的抑制剂,其IC50 值为12 nM。TRi-1 可用于肿瘤治疗,且线粒体毒性很小。
Cas No.: 246020-68-8
名称: 2-((4-chlorophenyl)sulfonyl)-6-methoxy-3-nitropyridine
别名:
SMILES: O=[N+](C1=CC=C(OC)N=C1S(=O)(C2=CC=C(Cl)C=C2)=O)[O-]
分子式: C12H9ClN2O5S
分子量: 328.723
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: TRi-1 (TXNRD1 inhibitor 1) is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1) with anticancer potential, 5- to 10-fold higher specificity for TXNRD1 over TXNRD2; inhibits cellular TXNRD activity with equal or greater potency compared to that of Auranofin with no effect on cellular GSH concentrations, efficiently activates c-Jun N-terminal kinase (JNK) and p38 phosphorylation; shows cytotoxicity profile against the NCI-60 cell panel with mean IC50 of 6.41 uM; impairs growth and viability of human tumor xenografts and syngeneic mouse tumors while having little mitochondrial toxicity and being better tolerated than auranofin.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_1131_DC22309_246020-68-8
COA
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