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AF-2364 or AdjudinTM, also known as 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide, is a less toxic but functionally similar analogue of Lonidamine (LND). AF-2364 has been shown to disrupt adherens junctions (AJs) between Sertoli cells and round and elongated spermatids in the adult rat and has been tested as a potential male contraceptive. In 2006, AF-2364 was conjugated to a recombinant follicle-stimulating hormone mutant protein, which served as its 'carrier' to Sertoli cells in the testis. This study is now moving towards human trials, though some major issues still need to be resolved. Recent research revealed a similar AF-2364-induced inhibition of spermatogenesis in the rabbit. However, no published studies have determined the effects of AF-2364 on human sperm function or fertility in general. As LND can inhibit oxygen consumption and block energy metabolism in tumour cells by targeting the mitochondria permeability transition (PT) pore and causing the loss of ΔΨm, we wondered whether AF-2364 would target human sperm mitochondria to influence sperm function and thus warrant further development into a spermicide candidate. For the detailed information of Adjudin (AF-2364), the solubility of Adjudin (AF-2364) in water, the solubility of Adjudin (AF-2364) in DMSO, the solubility of Adjudin (AF-2364) in PBS buffer, the animal experiment (test) of Adjudin (AF-2364), the cell expriment (test) of Adjudin (AF-2364), the in vivo, in vitro and clinical trial test of Adjudin (AF-2364), the EC50, IC50,and affinity,of Adjudin (AF-2364), For the detailed information of Adjudin (AF-2364), the solubility of Adjudin (AF-2364) in water, the solubility of Adjudin (AF-2364) in DMSO, the solubility of Adjudin (AF-2364) in PBS buffer, the animal experiment (test) of Adjudin (AF-2364), the cell expriment (test) of Adjudin (AF-2364), the in vivo, in vitro and clinical trial test of Adjudin (AF-2364), the EC50, IC50,and affinity,of Adjudin (AF-2364), Please contact DC Chemicals. |
