L-778123 HCl

产品编号: DC8803 Featured
L-778123 HCl
结构式
253863-00-2
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中国地区超过5000个高品质化合物库存
应用领域
L-778123盐酸盐是FPTase和GGPTase-I双重抑制剂, IC50值分别为2 nM 和 98 nM。
Cas No.: 253863-00-2
名称: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride
别名: L-778123,L 778123,L778123
SMILES: N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1.[H]Cl
分子式: C22H20ClN5O
分子量: 405.88
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed .
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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