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Doxapram

产品编号: DC9664 Featured
Doxapram
结构式
309-29-5
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中国地区超过5000个高品质化合物库存
应用领域
Doxapram能抑制TASK-1，TASK-3和TASK-1/TASK-3异二聚体通道，EC50分别为410 nM，37 μM和9 μM。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 309-29-5
名称:
别名: Dopram; Stimulex; Respiram
SMILES: CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4
分子式: C24H30N2O2
分子量: 378.51
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Doxapram is a respiratory stimulant. Doxapram (15-150 microM) also evoked 3H overflow in a concentration dependent manner, and doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 microM). Analysis of released tritiated compounds suggested that doxapram preferentially stimulated the release of dopamine. Our results indicate that the mechanism of action of doxapram shares similarities with that of hypoxia in the carotid body . Doxapram (1-100 microM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50 approximately 13 microM). doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions. Doxapram (10 microM) was without effect on L-type Ca2+ channel currents recorded under conditions where K+ channel activity was minimized and was also without significant effect on K+ currents recorded in the neuronal cell line NG-108 15, suggesting a selective effect on carotid body type I cells. The effects of doxapram on type I cells show similarities to those of the physiological stimuli of the carotid body, suggesting that doxapram may share a similar mechanism of action in stimulating the intact organ.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2700_DC9664_309-29-5
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