Madrasin

产品编号: DC9693 Featured
Madrasin
结构式
374913-63-0
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中国地区超过5000个高品质化合物库存
应用领域
Madrasin (DDD00107587) 是一种剪接抑制剂,可在体外阻止剪接中间体和产物的形成,并干扰剪接体组装途径中的一个或多个早期步骤。Madrasin 还能在体外抑制 pre-mRNA 的剪接,并修饰细胞中内源性 pre-mRNA 的剪接。
Cas No.: 374913-63-0
名称:
别名:
SMILES: COC(C=C1)=CC2=C1C(C)=NC(NC3=NC(C(C)=C(C)N3)=O)=N2
分子式: C16H17N5O2
分子量: 311.34
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2723_DC9693_374913-63-0
COA
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