LY364947

产品编号: DC6305 Featured
LY364947
结构式
396129-53-6
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中国地区超过5000个高品质化合物库存
应用领域
LY-364947 是一种有效的,ATP 竞争性的 TGFβR-I 抑制剂,IC50 值为 59 nM,是对 TGFβR-II 选择性的 7 倍。
Cas No.: 396129-53-6
名称: N/A
别名: LY 364947,LY-364947
SMILES: C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4
分子式: C17H12N4
分子量: 272.3
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: LY364947 is an ATP competitive and tight-binding inhibitor, inhibiting phosphorylation of P-Smad3 by TGFβR-I kinase with Ki of 28 nM. LY364947 inhibits in vivo Smad2 phosphorylation within the NMuMg cells with IC50 of 135 nM. LY364947 reverses TGF-β-media
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_1481_DC6305_396129-53-6
COA
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