BML-277

产品编号: DC8270 Featured
BML-277
结构式
516480-79-8
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中国地区超过5000个高品质化合物库存
应用领域
BML-277 是一种选择性的检测点激酶 2 (Chk2) 抑制剂,IC50 为 15 nM。
Cas No.: 516480-79-8
名称:
别名: Chk2 Inhibitor II; C 3742; BML277; BML 277
SMILES: C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
分子式: C20H14ClN3O2
分子量: 363.8
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: BML-277 (C 3742) is a selective Chk2 (checkpoint kinase 2) inhibitor with an IC50 of 15 nM.BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks. This is suggestive of BML-277's use as an adjuvant for radiation therapy in cancer. BML-277 is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. It has also been found to weakly inhibit 31 other kinases For the detailed information of BML-277, the solubility of BML-277 in water, the solubility of BML-277 in DMSO, the solubility of BML-277 in PBS buffer, the animal experiment (test) of BML-277, the cell expriment (test) of BML-277, the in vivo, in vitro and clinical trial test of BML-277, the EC50, IC50,and affinity,of BML-277, For the detailed information of BML-277, the solubility of BML-277 in water, the solubility of BML-277 in DMSO, the solubility of BML-277 in PBS buffer, the animal experiment (test) of BML-277, the cell expriment (test) of BML-277, the in vivo, in vitro and clinical trial test of BML-277, the EC50, IC50,and affinity,of BML-277, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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