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CP-640186 hydrochloride

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CP-640186 hydrochloride
结构式
591778-70-0
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中国地区超过5000个高品质化合物库存
应用领域
CP-640186 hydrochloride是一种有效且可透过细胞的乙酰辅酶A羧化酶 (ACC)抑制剂，抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的 IC50为53 nM和61 nM。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 591778-70-0
名称:
别名:
SMILES: O=C([C@H]1CN(C2CCN(C(C3=C(C=CC=C4)C4=CC5=C3C=CC=C5)=O)CC2)CCC1)N6CCOCC6
分子式: C30H36ClN3O3
分子量: 522.08
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: CP-640186 Hcl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. IC50 value: 53 nM/61 nM (rat liver ACC1/skeletal muscle ACC2) in vitro: CP-640186, also inhibited both isozymes with IC50s of ~55 nM but was 2–3 times more potent than CP-610431 in inhibiting HepG2 cell fatty acid and TG synthesis. CP-640186 also stimulated fatty acid oxidation in C2C12 cells (ACC2) and in rat epitrochlearis muscle strips with EC50s of 57 nM and 1.3 uM. in vivo: In rats, CP-640186 lowered hepatic, soleus muscle,quadriceps muscle, and cardiac muscle malonyl-CoA with ED50s of 55, 6, 15, and 8 mg/kg. Consequently, CP-640186 inhibited fatty acid synthesis in rats, CD1 mice,and ob/ob mice with ED50s of 13, 11, and 4 mg/kg, and stimulated rat whole body fatty acid oxidation with an ED50 of ~30 mg/kg.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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