NSC23005 free acid

产品编号: DC9989 Featured
NSC23005 free acid
结构式
6314-70-1
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中国地区超过5000个高品质化合物库存
应用领域
4-(cyclohexylsulfamoyl)benzoic acid
Cas No.: 6314-70-1
名称: 4-(N-cyclohexylsulfamoyl)benzoate
别名: NSC 23005,NSC-23005
SMILES: O=C([O-])C1=CC=C(S(=O)(NC2CCCCC2)=O)C=C1
分子式: C13H16O4S
分子量: 282.5
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: NSC23005 is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. InVitro: NSC23005 sodium is a novel class of INK4C (p18INK4C or p18) small molecule inhibitor (p18SMIs), which is initially found by in silico 3D screening. NSC23005 sodium shows the most potent bioactivity in hematopoietic stem cells (HSCs) expansion (ED50=5.21 nM). Notably, NSC23005 sodium does not show significant cytotoxicity toward 32D cells or HSCs, nor does it augment leukemia cell proliferation. NSC23005 sodium (ED50=5.21 nM), shows no activity in promoting the proliferation of leukemia cells. InVivo: NSC23005 sodium selectively promote HSCs division by inhibiting p18, thereby activating CDK4/6. NSC23005 sodium is a novel and effective p18 inhibitor in promoting HSCs expansion in both murine and human models.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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