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DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. For the detailed information of L-189, the solubility of L-189 in water, the solubility of L-189 in DMSO, the solubility of L-189 in PBS buffer, the animal experiment (test) of L-189, the cell expriment (test) of L-189, the in vivo, in vitro and clinical trial test of L-189, the EC50, IC50,and affinity,of L-189, For the detailed information of L-189, the solubility of L-189 in water, the solubility of L-189 in DMSO, the solubility of L-189 in PBS buffer, the animal experiment (test) of L-189, the cell expriment (test) of L-189, the in vivo, in vitro and clinical trial test of L-189, the EC50, IC50,and affinity,of L-189, Please contact DC Chemicals. |
